vitamin d simulator for the population mean

Vitamin D metabolises into 25-hydroxyvitamin D, “25(OH)D” in the liver

• Vitamin D deficiency: serum concentration of 25(OH)D < 25 nmol/L

• Vitamin D sufficiency: serum concentration of 25(OH)D ≥ 50 nmol/L

The goal of vitamin D supplementation should be to reach 25(OH)D ≥ 50 nmol/L

The app simulates how serum 25(OH)D is expected to change at daily vitamin D3 dosing

The model predicts the average for adults without conditions that affect the absorption, metabolism and excretion of vitamin D

The blue band marks 10-90% prediction intervals of the predicted population mean

The model was developed based on a naïve pooled model from the following publication:

Huang, Z. & You, T. (2021). Personalise vitamin D3 using physiologically based pharmacokinetic modelling. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 10(7), 723-734. doi:10.1002/psp4.12640

Licence: This is an open access article under the terms of the Creative Commons Attribution-­ NonCommercial-­ NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-­commercial and no modifications or adaptations are made.

This simulator is the property of Beyond Consulting ltd.