Drug metabolism and pharmacokinetics. An emphasis is on toxicokinetics which elucidates the absorption, distribution, metabolism and excretion of a toxicants and xenobiotics in relation to time. 

TMDD (target mediated drug disposition) relevant to both small and large molecules that are associated with cell surface targets 

MABEL Approaches (Minimum Anticipated Biological Effect Level): a safety methodology used to calculate the starting dose for First-in-Human (FIH) clinical trials, particularly for high-risk biological drugs like immunomodulators and monoclonal antibodies